Sodium 4-Phenylbutyrate Attenuates Myocardial Reperfusion Injury by Reducing the Unfolded Protein Response | Zendy

Osamu Takatori | Zendy; Soichiro Usui | Zendy; Masaki Okajima | Zendy; Shuichi Kaneko | Zendy; Hiroshi Ootsuji | Zendy; Shinichiro Takashima | Zendy; Daisuke Kobayashi | Zendy; Hisayoshi Murai | Zendy; Hiroshi Furusho | Zendy; Masayuki Takamura | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Sodium 4-Phenylbutyrate Attenuates Myocardial Reperfusion Injury by Reducing the Unfolded Protein Response

Author(s) -

Osamu Takatori,

Soichiro Usui,

Masaki Okajima,

Shuichi Kaneko,

Hiroshi Ootsuji,

Shinichiro Takashima,

Daisuke Kobayashi,

Hisayoshi Murai,

Hiroshi Furusho,

Masayuki Takamura

Publication year - 2016

Publication title -

journal of cardiovascular pharmacology and therapeutics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.787

H-Index - 50

eISSN - 1940-4034

pISSN - 1074-2484

DOI - 10.1177/1074248416679308

Subject(s) - medicine , cardioprotection , unfolded protein response , cardiac function curve , reperfusion injury , endocrinology , phenylbutyrate , myocardial infarction , apoptosis , pharmacology , heart failure , ischemia , biochemistry , chemistry

The unfolded protein response (UPR) plays a pivotal role in ischemia-reperfusion (I/R) injury in various organs such as heart, brain, and liver. Sodium 4-phenylbutyrate (PBA) reportedly acts as a chemical chaperone that reduces UPR. In the present study, we evaluated the effect of PBA on reducing the UPR and protecting against myocardial I/R injury in mice.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research