Open AccessTherapeutic Potential of Selenium and Selenium Compounds in Cervical Cancer
Author(s) -
Ewa Jabłońska,
Qi Li,
Edyta Reszka,
Edyta Wieczorek,
Kateryna Tarhonska,
Tong Wang
Publication year - 2021
Publication title -
cancer control
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.794
H-Index - 72
eISSN - 1526-2359
pISSN - 1073-2748
DOI - 10.1177/10732748211001808
Subject(s) - medicine , selenium , cervical cancer , malignancy , cancer , immune system , oncology , cancer research , immunology , bioinformatics , biology , materials science , metallurgy
Cervical cancer is a common female cancer. It is strongly associated with human papillomavirus (HPV) infection. However, HPV infection alone is not sufficient to induce cervical cancer because its development is dependent on the coexistence of several factors that enable the virus to overcome the host immune system. These include individual genetic background, environmental factors, or diet, including dietary selenium intake. Selenium is an essential trace element with antiviral properties and has been shown to exert antitumor effects. Surprisingly, the role of selenium in cervical cancer has not been studied as intensively as in other cancers. Here, we have summarized the existing experimental data on selenium and cervical cancer. It may be helpful in evaluating the role of this nutrient in treatment of the mentioned malignancy as well as in planning further studies in this area.