Open AccessInterventions to Promote Oral Medication Adherence in the Pediatric Chronic Illness Population: A Systematic Review From the Children’s Oncology Group
Author(s) -
Kelly Coyne,
Katherine A Trimble,
Ashley Lloyd,
Laura Petrando,
Jennie Pentz,
Kari Van Namen,
Andrea J. Fawcett,
Catherine M. Laing
Publication year - 2019
Publication title -
journal of pediatric oncology nursing
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.471
H-Index - 50
eISSN - 1532-8457
pISSN - 1043-4542
DOI - 10.1177/1043454219835451
Subject(s) - medicine , psychological intervention , pediatric oncology , psychosocial , dosing , intervention (counseling) , pill , population , grading (engineering) , intensive care medicine , pediatrics , cancer , psychiatry , nursing , civil engineering , environmental health , engineering
Pediatric oncology protocols frequently include multiple oral medications administered at varied dosing schedules, often for prolonged periods of time. Nonadherence to protocol-directed oral medications may place patients at increased risk for morbidity and mortality. The purpose of this systematic review was to evaluate the existing body of evidence to determine best-practice recommendations regarding interventions for oral medication adherence in children and adolescents with cancer. Twenty-four articles were systematically reviewed and evaluated according to the Grading of Recommendations, Assessment, Development, and Evaluation criteria; 2 studies focused on the pediatric oncology population, and the remaining 22 studies focused on other chronic illnesses of childhood. A variety of interventions to increase oral medication adherence in children were identified, including pill swallowing, technology, incentivization, education-based intervention, psychosocial support-based intervention, and combination intervention. Most interventions were shown to have some benefit in pediatrics, most in the non-oncology setting. The overall synthesis of the literature indicates that nonadherence to oral medications is a prevalent problem in pediatrics, and much work is needed to address this problem, particularly in pediatric oncology.