Open AccessOlfactory ganglioneuroblastoma in a dog: case report and literature review
Author(s) -
Ashley M. Romano,
Chad Frank
Publication year - 2021
Publication title -
journal of veterinary diagnostic investigation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.529
H-Index - 78
eISSN - 1943-4936
pISSN - 1040-6387
DOI - 10.1177/10406387211022864
Subject(s) - ganglioneuroblastoma , synaptophysin , pathology , histopathology , cribriform plate , skull , immunohistochemistry , ganglioneuroma , ganglion , anatomy , esthesioneuroblastoma , biology , neuroblast , neoplasm , medicine , neuroblastoma , nasal cavity , neuroscience , cell culture , genetics , neurogenesis
A 7-y-old, intact male Alaskan Malamute was presented with a 3-mo history of stertor and epistaxis. Computed tomography of the skull revealed generalized loss of gas throughout both nasal passages with replacement by a soft tissue mass that traversed the cribriform plate. Histopathology revealed neoplastic neuroblast cells arranged in anastomosing cords, as well as separately located aggregates of ganglion cells. Both neoplastic cell populations demonstrated immunoreactivity to MAP-2, TuJ-1, and synaptophysin. Neuroblastic cells additionally exhibited punctate immunoreactivity to MCK and CK8/18. We document here both the positive neural immunohistochemical markers for this neoplasm, as well as propose possible histomorphologic variants.