Open AccessMiR-204/ZEB2 axis functions as key mediator for MALAT1-induced epithelial–mesenchymal transition in breast cancer
Author(s) -
Yuzhou Wang,
Yujia Zhou,
Zhicheng Yang,
Baoying Chen,
Wennan Huang,
Yongyuan Liu,
Ying Zhang
Publication year - 2017
Publication title -
tumor biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.055
H-Index - 84
eISSN - 1423-0380
pISSN - 1010-4283
DOI - 10.1177/1010428317690998
Subject(s) - malat1 , epithelial–mesenchymal transition , breast cancer , cancer research , competing endogenous rna , biomarker , long non coding rna , biology , microrna , mediator , metastasis , psychological repression , cancer , rna , microbiology and biotechnology , gene , gene expression , genetics
Long non-coding RNAs recently were identified as key mediators of cancer metastasis. This study provided evidence that long non-coding RNA MALAT1 was up-regulated in breast cancer tissues and cell lines. MALAT1 promoted cancer cell invasion through inducing epithelial–mesenchymal transition. Interestingly, we revealed there was a reciprocal repression between MALAT1 and miR-204. ZEB2 was identified as a downstream target of miR-204 and MALAT1 exerted its function mainly through the miR-204/ZEB2 axis. Our findings suggested that MALAT1 may serve as a new diagnostic biomarker and therapy target for breast cancer.