Open AccessPeroral Exposure to Cannabis Sativa Ethanol Extract Caused Neuronal Degeneration and Astrogliosis in Wistar Rats’ Prefrontal Cortex
Author(s) -
Olatunji Sunday Yinka,
Ogunnaike Philip Olubunmi,
Ayodeji Zabdiel Abijo,
Owolabi Joshua Oladele,
Adelodun Stephen Taiye,
Adeoye Ayodele,
OA Fasesan,
Olanrewaju John Afees,
Adegbite Ademola Kayode
Publication year - 2022
Publication title -
annals of neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.545
H-Index - 19
eISSN - 0976-3260
pISSN - 0972-7531
DOI - 10.1177/09727531221120988
Subject(s) - prefrontal cortex , dopamine , open field , glial fibrillary acidic protein , medicine , hippocampus , endocrinology , pharmacology , neurotransmitter , immunohistochemistry , psychiatry , central nervous system , cognition
Despite widespread concerns about its possible side effects, notably on the prefrontal cortex (PFC), which mediates cognitive processes, the use of Cannabis sativa as a medicinal and recreational drug is expanding exponentially. This study evaluated possible behavioral alterations, neurotransmitter levels, histological, and immunohistochemical changes in the PFC of Wistar rats exposed to Cannabis sativa .