Open AccessPredictive Value of Combination of D-dimer and Fibrinogen in Diagnosing Acute CVST
Author(s) -
Abhishek Pathak,
Varun Kumar Singh,
Anand Kumar,
Vijaya Nath Mishra,
Deepika Joshi,
Rameshwar Nath Chaurasia
Publication year - 2021
Publication title -
annals of neurosciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.545
H-Index - 19
eISSN - 0976-3260
pISSN - 0972-7531
DOI - 10.1177/09727531211063138
Subject(s) - d dimer , medicine , fibrinogen , latex fixation test , gastroenterology , immunology , antibody
Background: Cerebral venous sinus thrombosis (CVST) is an uncommon subtype of stroke, and the role of D-dimer and fibrinogen in early diagnosis of CVST has been studied with varying results. The present study aims to study the role of the combination of D-dimer and fibrinogen in early diagnosis of acute CVST.Methods: Forty consecutive confirmed acute CVST cases admitted at a tertiary care center were recruited for the study. D-dimer and fibrinogen were assessed by a rapid semiquantitative latex agglutination assay.Results: Out of the 40 CVST patients, 21 (52.50%) were females. The mean age of the patients was 37.58 years ± 19.17 years. Common clinical features were headache ( N = 38 [95%]), papilloedema ( N = 15 [37.5%]), and seizures ( N = 12 [30%]). Although the sensitivity (75%) of the combination of D-dimer and fibrinogen assay was lower than that of D-dimer or fibrinogen alone, the specificity and positive predictive value (75% each) was higher.Conclusion: The combination of D-dimer and fibrinogen testing may aid in an early diagnosis of acute CVST and in better management.