Characterization of Type-I IFN subtype autoantibodies and activity in SLE serum and urine | Zendy

Bethany D. Harris | Zendy; Srilalitha Kuruganti | Zendy; Ashlesha Deshpande | Zendy; Paul Goepfert | Zendy; Winn Chatham | Zendy; Mark R. Walter | Zendy

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Characterization of Type-I IFN subtype autoantibodies and activity in SLE serum and urine

Author(s) -

Bethany D. Harris,

Srilalitha Kuruganti,

Ashlesha Deshpande,

Paul Goepfert,

Winn Chatham,

Mark R. Walter

Publication year - 2020

Publication title -

lupus

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.069

H-Index - 103

eISSN - 1477-0962

pISSN - 0961-2033

DOI - 10.1177/0961203320935976

Subject(s) - autoantibody , interferon , medicine , immunology , antibody , pathogenesis , immune system , cytokine , urine

Type-I interferons contribute to pathogenesis in systemic lupus erythematosus, including nephritis. Interferons consist of a family of 16 proteins yet are often characterized in patients without knowledge of the specific interferon subtypes involved. Different interferons may function in the kidneys, and other organs, relative to what is often measured in patient blood. Moreover, antibodies to interferons may potentially modulate systemic or organ-specific interferon activity. The aim of this study was to characterize global interferon activity levels and identify autoantibodies to the 12 interferon α subtypes in patient serum and urine.

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