Open AccessCharacterization of Type-I IFN subtype autoantibodies and activity in SLE serum and urine
Author(s) -
Bethany Harris,
Srilalitha Kuruganti,
Ashlesha Deshpande,
Paul Goepfert,
W. Winn Chatham,
Mark R. Walter
Publication year - 2020
Publication title -
lupus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.069
H-Index - 103
eISSN - 1477-0962
pISSN - 0961-2033
DOI - 10.1177/0961203320935976
Subject(s) - autoantibody , interferon , medicine , immunology , antibody , immune system , pathogenesis , urine , cytokine
Type-I interferons contribute to pathogenesis in systemic lupus erythematosus, including nephritis. Interferons consist of a family of 16 proteins yet are often characterized in patients without knowledge of the specific interferon subtypes involved. Different interferons may function in the kidneys, and other organs, relative to what is often measured in patient blood. Moreover, antibodies to interferons may potentially modulate systemic or organ-specific interferon activity. The aim of this study was to characterize global interferon activity levels and identify autoantibodies to the 12 interferon α subtypes in patient serum and urine.