Open AccessRole of tissue factor in thrombosis in antiphospholipid antibody syndrome
Author(s) -
Jeremiah Boles,
Nigel Mackman
Publication year - 2010
Publication title -
lupus
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.069
H-Index - 103
eISSN - 1477-0962
pISSN - 0961-2033
DOI - 10.1177/0961203309360810
Subject(s) - antiphospholipid syndrome , medicine , tissue factor , thrombosis , pathophysiology , immunology , lupus anticoagulant , antibody , venous thrombosis , systemic lupus erythematosus , coagulation , disease
Antiphospholipid syndrome (APS) is an acquired autoimmune disorder defined by the presence of an antiphospholipid antibody (aPL) and the occurrence of at least one associated clinical condition that includes venous thrombosis, arterial thrombosis or pregnancy morbidity. The aPL detected in APS have long been thought to have a direct prothrombotic effect in vivo. However, the pathophysiology underlying their coagulopathic effect has not been defined. Emerging data suggest a role for the procoagulant protein tissue factor (TF). In this review we provide an overview of TF, describe mouse models used in the evaluation of the role of TF in thrombosis, as well as summarize recent work on TF and APS.