Open AccessCerebral Autoregulation–Guided Optimal Blood Pressure in Sepsis-Associated Encephalopathy: A Case Series
Author(s) -
Kathryn Rosenblatt,
Keenan A. Walker,
Carrie Goodson,
Elsa Olson,
Dermot P. Maher,
Charles H. Brown,
Paul Nyquist
Publication year - 2019
Publication title -
journal of intensive care medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 58
eISSN - 1525-1489
pISSN - 0885-0666
DOI - 10.1177/0885066619828293
Subject(s) - medicine , cerebral autoregulation , autoregulation , cerebral perfusion pressure , encephalopathy , blood pressure , sepsis , anesthesia , mean arterial pressure , cerebral blood flow , glasgow coma scale , cerebral edema , intracranial pressure , hemodynamics , cardiology , heart rate
Impaired cerebral autoregulation and cerebral hypoperfusion may play a critical role in the high morbidity and mortality in patients with sepsis-associated encephalopathy (SAE). Bedside assessment of cerebral autoregulation may help individualize hemodynamic targets that optimize brain perfusion. We hypothesize that near-infrared spectroscopy (NIRS)-derived cerebral oximetry can identify blood pressure ranges that enhance autoregulation in patients with SAE and that disturbances in autoregulation are associated with severity of encephalopathy.