Cerebral Autoregulation–Guided Optimal Blood Pressure in Sepsis-Associated Encephalopathy: A Case Series | Zendy

Kathryn Rosenblatt | Zendy; Keenan A. Walker | Zendy; Carrie Goodson | Zendy; Elsa Olson | Zendy; Dermot P. Maher | Zendy; Charles H. Brown | Zendy; Paul Nyquist | Zendy

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Cerebral Autoregulation–Guided Optimal Blood Pressure in Sepsis-Associated Encephalopathy: A Case Series

Author(s) -

Kathryn Rosenblatt,

Keenan A. Walker,

Carrie Goodson,

Elsa Olson,

Dermot P. Maher,

Charles H. Brown,

Paul Nyquist

Publication year - 2019

Publication title -

journal of intensive care medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.866

H-Index - 58

eISSN - 1525-1489

pISSN - 0885-0666

DOI - 10.1177/0885066619828293

Subject(s) - medicine , cerebral autoregulation , autoregulation , cerebral perfusion pressure , encephalopathy , sepsis , blood pressure , anesthesia , mean arterial pressure , glasgow coma scale , cerebral blood flow , intracranial pressure , cerebral edema , hemodynamics , cardiology , heart rate

Impaired cerebral autoregulation and cerebral hypoperfusion may play a critical role in the high morbidity and mortality in patients with sepsis-associated encephalopathy (SAE). Bedside assessment of cerebral autoregulation may help individualize hemodynamic targets that optimize brain perfusion. We hypothesize that near-infrared spectroscopy (NIRS)-derived cerebral oximetry can identify blood pressure ranges that enhance autoregulation in patients with SAE and that disturbances in autoregulation are associated with severity of encephalopathy.

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