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Overdose of Intravenous Fat Emulsion in a Preterm Infant: Case Report
Author(s) -
Fairchild Karen D.,
Patterson Angela,
Gumpper Karl F.
Publication year - 1999
Publication title -
nutrition in clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.725
H-Index - 71
eISSN - 1941-2452
pISSN - 0884-5336
DOI - 10.1177/088453369901400304
Subject(s) - medicine , lethargy , fat emulsion , respiratory distress , coma (optics) , parenteral nutrition , apnea , enteral administration , intensive care , pediatrics , anesthesia , metabolic acidosis , intensive care medicine , physics , optics
IV fat emulsion therapy is essential for providing optimum nutrition for neonates who are unable to tolerate enteral feeding. The method of administering IV lipids in many neonatal intensive care units allows the possibility of accidental overdose. We report the case of a massive overdose of Intralipid (Clintec, Deerfield, IL) to a 32‐week‐gestation infant. On day 5 of life, the patient received 250 mL of 20% lipid emulsion IV over 1 hour (24 g of lipid/kg body wt). The serum triglyceride level peaked at 12,900 mg/dL, and the infant developed respiratory distress, metabolic acidosis, lethargy, and apnea. The infant was treated with double volume exchange transfusion, with rapid resolution of clinical symptoms. There was no evidence of clinical sequelae of the lipid overdose, either immediately after the event or during 1 year of neurodevelopmental follow‐up.