Premium
Aluminum Content of Neonatal Parenteral Nutrition Solutions
Author(s) -
Huston Robert K.,
Heisel Carl F.,
Vermillion Benjamin R.,
Christensen J. Mark,
Minc Leah
Publication year - 2017
Publication title -
nutrition in clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.725
H-Index - 71
eISSN - 1941-2452
pISSN - 0884-5336
DOI - 10.1177/0884533616668789
Subject(s) - calcium , medicine , parenteral nutrition , sodium , nuclear chemistry , food science , zoology , chemistry , organic chemistry , biology
Calcium chloride (CaCl 2 ) has been the only calcium additive available in the United States that has a low aluminum (Al) content. Calcium gluconate in glass vials (CaGluc‐Gl) has a high Al content while calcium gluconate in plastic vials (CaGluc‐Pl) has a low Al content. The purpose of this study was to measure Al concentrations in neonatal parenteral nutrition (PN) solutions prepared using various calcium additives. Methods: Samples of solutions compounded with CaCl 2 or CaGluc‐Gl and sodium phosphate (NaPhos) as well as CaGluc‐Pl and sodium glycerophosphate (NaGP) with and without cysteine were analyzed for Al content. Samples of the cysteine and calcium gluconate additives were also sent for analysis. Results: Solutions containing CaCl 2 and CaGlu‐Pl had mean Al concentrations of 1.2–2.3 mcg/dL, while those with CaGlu‐Gl had mean concentrations of 14.6–15.1 mcg/dL. Solutions made with NaGP were low in Al content. The measured Al content of 2 lots of the cysteine additive were 168 ± 23 mcg/L and 126 ± 5 mcg/L. The Al concentration equalled 2730 ± 20 mcg/L for the CaGlu‐Gl additive and 310 ± 80 mcg/L for the CaGlu‐Pl additive. Conclusion: The study indicates that solutions containing CaCl 2 or CaGluc‐Pl and NaPhos or NaGP are low in Al content. Using these options for calcium and phosphate additives can limit aluminum intake from neonatal PN to levels within the Food and Drug Administration guideline of ≤5 mcg/kg/d.