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Improved Tolerance to a New Amino Acid–Based Formula by Infants With Cow's Milk Protein Allergy
Author(s) -
Jirapinyo Pipop,
Densupsoontorn Narumon,
Kangwanpornsiri Channagan,
Wongarn Renu,
Tirapongporn Hathaichanok,
Chotipanang Kwanjai,
Phuangphan Phakkanan
Publication year - 2016
Publication title -
nutrition in clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.725
H-Index - 71
eISSN - 1941-2452
pISSN - 0884-5336
DOI - 10.1177/0884533616639108
Subject(s) - medicine , elimination diet , food allergy , placebo , allergy , milk allergy , pediatrics , infant formula , corn starch , starch , gastroenterology , food science , immunology , chemistry , alternative medicine , pathology
Background: Prevalence and severity of cow's milk protein allergy (CMA) in infants are increasing. A proportion of infants with CMA still elicit signs and symptoms of CMA while ingesting commercial amino acid–based formulas (AAFs). We propose that protein in glucose polymers (GPs) derived from corn starch in the AAFs might be the cause of intolerance to AAF in some infants. We thus have produced small molecules of GPs from rice starch, eliminating the protein fraction from them, and subsequently used them as the sole source of carbohydrate in a new amino acid–based formula (NAAF). Methods: The efficacy of the NAAF was compared with that of an AAF in a double‐blind, placebo‐controlled food challenge (DBPCFC) in young infants with CMA aged <4 months. Infants consumed each formula for 14 days before switching to the other one. If no respiratory, dermatologic, and gastrointestinal symptom occurred, it was considered tolerance. After the challenge, infants consumed the tolerated formula for 4 weeks to prove real tolerance to that formula. Results: Of 46 infants, 23 were intolerant to the AAF, of whom 7 (30.4%) were also intolerant to the NAAF. Sixteen of the 23 infants who were intolerant to the AAF could tolerate the NAAF ( P < .05). The minimal important difference of decreasing percentage of intolerance to the NAAF was 34.8% compared with the infants who were intolerant to the AAF. Conclusion: The NAAF is better tolerated than a commercially available AAF for the management of infants with CMA.