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Consequences of Gastrointestinal Surgery on Drug Absorption
Author(s) -
Titus Rachel,
Kastenmeier Andrew,
Otterson Mary F.
Publication year - 2013
Publication title -
nutrition in clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.725
H-Index - 71
eISSN - 1941-2452
pISSN - 0884-5336
DOI - 10.1177/0884533613490740
Subject(s) - medicine , dosing , drug , absorption (acoustics) , food and drug administration , small intestine , pharmacology , intensive care medicine , physics , acoustics
Gastrointestinal (GI) surgery associated with resection or bypass can affect the absorption and kinetics of certain drugs. The goal of this article is 3‐fold: (1) highlight the physiologic changes associated with selected GI surgeries (specifically gastric, small intestine, and colon), (2) review the implications for drug and nutrient absorption, and (3) suggest modifications of the pharmacologic agents, dosing regimens, and routes of delivery. Few large trials are available to use as references, but there is a wealth of individual reports and small series. Understanding the predictable challenges of drug administration in these patients will improve care.