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Clinical Research: Is Routine Vitamin K Supplementation Required in Hospitalized Patients Receiving Parenteral Nutrition?
Author(s) -
Duerksen Donald R.,
Papineau Noreen
Publication year - 2000
Publication title -
nutrition in clinical practice
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.725
H-Index - 71
eISSN - 1941-2452
pISSN - 0884-5336
DOI - 10.1177/088453360001500205
Subject(s) - medicine , parenteral nutrition , multivitamin , incidence (geometry) , vitamin , vitamin k deficiency , vitamin k , gastroenterology , physics , optics
Vitamin K is not a component of the multivitamin preparation added to parenteral nutrition solutions, and hospitalized patients receiving parenteral nutrition (PN) support are at risk of developing vitamin K deficiency. In this study, 70 consecutive patients receiving PN were followed prospectively to determine the incidence of a raised international normalized ratio (INR). Over a 3‐week period, 20% of patients developed a raised INR compared with baseline. All elevations were mild, with no patients developing clinical bleeding. An alternative to routinely supplementing vitamin K is monitoring INR and supplementing those individuals with elevated coagulation parameters.