Open AccessAscorbic Acid and Iron Supplement Treatment Improves Stem Cell–Mediated Cartilage Regeneration in a Minipig Model
Author(s) -
Ashok J. Theruvath,
Elhussein Elbadry Mahmoud,
Wei Wu,
Hossein Nejadnik,
Louise Kiru,
Tie Liang,
Stephen A. Felt,
Heike E. DaldrupLink
Publication year - 2021
Publication title -
the american journal of sports medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.021
H-Index - 221
eISSN - 1552-3365
pISSN - 0363-5465
DOI - 10.1177/03635465211005754
Subject(s) - ascorbic acid , cartilage , chondrogenesis , mesenchymal stem cell , transplantation , medicine , regeneration (biology) , in vivo , pathology , surgery , chemistry , anatomy , biology , microbiology and biotechnology , food science
The transplantation of mesenchymal stem cells (MSCs) into cartilage defects has led to variable cartilage repair outcomes. Previous in vitro studies have shown that ascorbic acid and reduced iron independently can improve the chondrogenic differentiation of MSCs. However, the combined effect of ascorbic acid and iron supplementation on MSC differentiation has not been investigated.