Open AccessDistinct Pattern of Inflammation of Articular Cartilage and the Synovium in Early and Late Hip Femoroacetabular Impingement
Author(s) -
Masahiko Haneda,
Muhammad Farooq,
Lei Cai,
Robert H. Brophy,
Regis J. O’Keefe,
John C. Clohisy,
Cecilia PascualGarrido
Publication year - 2020
Publication title -
the american journal of sports medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.021
H-Index - 221
eISSN - 1552-3365
pISSN - 0363-5465
DOI - 10.1177/0363546520935440
Subject(s) - femoroacetabular impingement , aggrecan , medicine , inflammation , synovitis , osteoarthritis , cartilage , adamts , pathology , matrix metalloproteinase , metalloproteinase , thrombospondin , arthritis , anatomy , surgery , articular cartilage , alternative medicine
The molecular mechanism of how femoroacetabular impingement (FAI) morphology leads to hip osteoarthritis (OA) is yet to be determined. The expression and location of inflammation-related molecules during early- and late-stage FAI have not been previously described. Moreover, the characterization of intra-articular inflammation away from the cam deformity as well as the nature of adjacent synovial tissue have also not been extensively reported.