Open AccessLack of association between CYP11B2 -344T/C polymorphism and transient ischemic attack in a Chinese population
Author(s) -
Jia Fan,
Yaoliang Shen,
Bin Chen,
Chunyang Xu,
Hongwei Ye,
Jian Wang,
Wenjun Zhou,
Yuefeng Sheng,
Feng Xu,
Peng Yang
Publication year - 2020
Publication title -
journal of international medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 57
eISSN - 1473-2300
pISSN - 0300-0605
DOI - 10.1177/0300060520947916
Subject(s) - genotype , medicine , allele , polymorphism (computer science) , allele frequency , gastroenterology , genetics , biology , gene
Objective This study investigated whether the CYP11B2 -344T/C polymorphism is correlated with transient ischemic attack (TIA) susceptibility.Methods We recruited 100 TIA patients and 100 control subjects and analyzed the CYP11B2 -344T/C polymorphism using restriction fragment length polymorphism (PCR–RFLP).Results The frequency in TIA patients and controls was 42% compared with 48% for TT genotypes, 51% compared with 45% for TC genotypes, and 7% compared with 7% for CC genotype, respectively. Allele frequencies in TIA patients and controls were 67.5% compared with 70.5% for T-allele and 32.5% compared with 29.5% for C-allele, respectively. No association between the CYP11B2 -344T/C polymorphism and TIA was observed in all comparisons.Conclusion Our data suggest that there was no association between the CYP11B2 -344T/C polymorphism and TIA in a Chinese population.