Open AccessAssociation between interleukin-8 −251A/T polymorphism and the risk of tuberculosis: A meta-analysis
Author(s) -
Qin Hu,
Haibo Hua,
Liang-Fu Zhou,
XianWu Zou
Publication year - 2020
Publication title -
journal of international medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 57
eISSN - 1473-2300
pISSN - 0300-0605
DOI - 10.1177/0300060520917877
Subject(s) - medicine , odds ratio , meta analysis , confidence interval , interleukin 8 , tuberculosis , polymorphism (computer science) , gastroenterology , genotype , pathology , genetics , gene , biology , cytokine
Objective The relationship between interleukin-8 ( IL8) −251A/T polymorphism and tuberculosis (TB) risk remains controversial. Therefore, the present meta-analysis was performed by retrieving relevant studies from the available literature.Methods We comprehensively searched three databases to identify eligible literature on the relationship of IL8 −251A/T polymorphism with TB risk, calculated pooled odds ratios (OR) with 95% confidence intervals (CI), and subsequent evaluated the heterogeneity and publication bias.Results We found that IL8 −251A/T polymorphism increased TB risk (AA vs. TT: OR = 2.86, 95%CI: 1.46–5.60; AT vs. TT: OR = 1.64, 95%CI: 1.15–2.34; dominant model: OR = 1.88, 95%CI: 1.24–2.86; recessive model: OR = 1.77, 95%CI: 1.17–2.69). Subgroup analyses based on race revealed that the IL8 −251A/T polymorphism might be associated with the risk of TB in African but not Asian individuals.Conclusion The IL8 −251A/T polymorphism might be related to the risk of TB. Nevertheless, large-scale studies should be performed to confirm the role of IL8 −251A/T polymorphism on TB risk.