The effect of thioctic acid on allodynia in a rat vincristine-induced neuropathy model | Zendy

Jimin Kahng | Zendy; Tae Kwan Kim | Zendy; Yong Eun Chung | Zendy; HongGee Kim | Zendy; Jeong Yeon Moon | Zendy

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The effect of thioctic acid on allodynia in a rat vincristine-induced neuropathy model

Author(s) -

Jimin Kahng,

Tae Kwan Kim,

Yong Eun Chung,

HongGee Kim,

Jeong Yeon Moon

Publication year - 2015

Publication title -

journal of international medical research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.421

H-Index - 57

eISSN - 1473-2300

pISSN - 0300-0605

DOI - 10.1177/0300060515569287

Subject(s) - thioctic acid , medicine , allodynia , anesthesia , vincristine , intraperitoneal injection , saline , pharmacology , hyperalgesia , lipoic acid , chemotherapy , chemistry , biochemistry , nociception , receptor , antioxidant , cyclophosphamide

Objective To investigate the antiallodynic effects of thioctic acid in vincristine-induced neuropathy in rats.Methods Neuropathy was induced in Sprague–Dawley rats via vincristine intraperitoneal injection. After 15 days, rats were investigated for the presence of mechanical and cold allodynia, and those with allodynia received intraperitoneal injection with normal saline or 1, 5, or 10 mg/kg thioctic acid. Mechanical and cold allodynia were assessed before treatment and at 15, 30, 60, 90, 150 and 180 min after treatment.Results Mechanical and cold allodynia were reduced by thioctic acid injection. The duration of effect increased with thioctic acid dose.Conclusion Thioctic acid may be an effective treatment for vincristine-induced neuropathy.

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