Open AccessRenal function, acute kidney injury and hospital mortality in patients with acute myocardial infarction
Author(s) -
Ying Liao,
Xingmo Dong,
Kaihong Chen,
Fang Yong,
Weiguo Li,
Guo-Yong Huang
Publication year - 2014
Publication title -
journal of international medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 57
eISSN - 1473-2300
pISSN - 0300-0605
DOI - 10.1177/0300060514541254
Subject(s) - medicine , acute kidney injury , renal function , odds ratio , myocardial infarction , creatinine , confidence interval , mortality rate , cardiology
Objectives To examine retrospectively the relationship between acute kidney injury (AKI) and acute myocardial infarction (AMI), and the association between estimated glomerular filtration rate (eGFR) at admission and AKI outcome.Methods AKI was defined as an increase in serum creatinine (SCr) by ≥0.3 mg/dl within 48 h or an increase in SCr to ≥1.5 times baseline within the first 7 days of hospitalization. Patients with AMI were divided into subgroups according to their eGFR at admission and the development of AKI.Results This study enrolled 396 patients with AMI; 48 (12.1%) developed AKI. In-hospital mortality was 39.6% (19/48) for patients with AKI compared with 7.5% (26/348) in those without AKI (odds ratio [OR] 8.11; 95% confidence interval [CI] 4.02, 16.39). The mortality rate was 35.7% (five of 14) in the eGFR ≥ 60 ml/min/1.73m 2 with AKI group (OR 6.21, 95% CI 1.50, 25.69) and 41.2% (14/34) in the eGFR < 60 ml/min/1.73m 2 with AKI group (OR 12.62, 95% CI 5.54, 28.74).Conclusions AKI development was common and associated with mortality in AMI patients with either preserved or impaired eGFR levels.