Open AccessAssociation between obesity, prostate-specific antigen level and prostate-specific antigen density in men with a negative prostate biopsy
Author(s) -
Jae Heon Kim,
Sang Wook Lee,
Jae Ho Kim,
Hee Jo Yang,
Seung Whan Doo,
Jong Hyun Yoon,
Doo Sang Kim,
Won Jae Yang,
Kwang Woo Lee,
Jun Mo Kim,
Chang-Ho Lee,
Soon Sun Kwon
Publication year - 2014
Publication title -
journal of international medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 57
eISSN - 1473-2300
pISSN - 0300-0605
DOI - 10.1177/0300060513518038
Subject(s) - medicine , body mass index , prostate specific antigen , prostate cancer , prostate , prostate biopsy , biopsy , urology , obesity , rectal examination , anthropometry , gynecology , cancer
Objective To determine the association between body mass index (BMI), serum prostate-specific antigen (PSA) level and PSA density (PSAD) in patients with an elevated serum PSA level but a negative prostate biopsy.Methods This retrospective study enrolled men with a negative prostate biopsy but a serum PSA level of 3.0–10 ng/ml. All men underwent anthropometric measurements, serum PSA determination and transrectal ultrasound examination. BMI was grouped according to the Asia-Pacific obesity criteria: nonobese (<25 kg/m 2 ) versus obese (≥25 kg/m 2 ). Partial correlation and linear regression models between PSA, PSAD and BMI were conducted after adjusting for age.Results A total of 907 men were enrolled in this study. On multivariate analyses, PSA showed no significant correlation with age or BMI, whereas PSAD had a negative correlation with age and BMI. Similar results were obtained when patients were categorized as having low (3.0 < PSA ≤ 6.5 ng/ml) or high PSA (6.5 < PSA ≤ 10.0 ng/ml) levels.Conclusion PSAD, but not PSA, demonstrated a significant negative correlation with BMI. This indicates that a new strategy including PSAD rather than simple PSA levels should be adopted in the study of obesity-adjusted PSA cut-offs.