Open AccessFatty liver and serum cholinesterase are independently correlated with HbA1c levels: Cross-sectional analysis of 5384 people
Author(s) -
Shūichi Katoh,
Markku Peltonen,
Takashi Wada,
Mikio Zeniya,
Yoichi Sakamoto,
Kazunori Utsunomiya,
Jaakko Tuomilehto
Publication year - 2014
Publication title -
journal of international medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 57
eISSN - 1473-2300
pISSN - 0300-0605
DOI - 10.1177/0300060513517485
Subject(s) - medicine , fatty liver , cross sectional study , body mass index , gastroenterology , cholinesterase , endocrinology , disease , pathology
Objectives: To examine the association between glycosylated haemoglobin (HbA1c) and fatty liver markers.Methods: This cross-sectional analysis stratified subjects into quintiles based on HbA1c. Fatty liver using ultrasonography scores (FLUS) were assigned as follows: 2 points, moderate or severe fatty liver; 1 point, mild fatty liver; and 0 points, normal liver. Subjects with viral hepatitis, alcohol intake >175 g/week or receiving hypoglycaemic treatment were excluded.Results: The study included 5384 subjects. Serum cholinesterase (ChE) and FLUS showed a significant graded increase with increasing HbA1c. In linear regression analysis stratified by body mass index (BMI) and age, ChE and FLUS were significantly associated with lower (1 + 2) and higher (3 + 4 + 5) HbA1c quintiles, respectively, independent of BMI and age.Conclusions: The findings show that both ChE and FLUS are significantly correlated with HbA1c, independent of BMI and age.