Open AccessInvestigation of neutrophil lymphocyte ratio and blood glucose regulation in patients with type 2 diabetes mellitus
Author(s) -
Fatih Sefil,
Kemal Türker Ulutaş,
Recep Dokuyucu,
Ahmet Taner Sümbül,
Erhan Yengil,
Abdullah Erman Yağız,
Erkan Yula,
İhsan Üstün,
Cumali Gökçe
Publication year - 2014
Publication title -
journal of international medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 57
eISSN - 1473-2300
pISSN - 0300-0605
DOI - 10.1177/0300060513516944
Subject(s) - medicine , leukocytosis , type 2 diabetes mellitus , diabetes mellitus , neutrophil to lymphocyte ratio , white blood cell , lymphocyte , pathogenesis , metabolic syndrome , absolute neutrophil count , gastroenterology , endocrinology , immunology , toxicity , neutropenia
Objective Leukocytosis is thought to be directly associated with the pathogenesis of atherosclerosis and metabolic syndrome. Increased white blood cell (WBC) count is related to cardiovascular disease in patients with type 2 diabetes mellitus; raised neutrophil lymphocyte ratio (NLR) is associated with metabolic syndrome. There is little information, however, concerning a correlation between glycosylated haemoglobin (HbA 1c ) and NLR. The aim of the present study was to investigate the relationship between NLR and blood glucose regulation.Methods This retrospective study was conducted in patients with type 2 diabetes mellitus, divided into two groups according to HbA 1c levels: group 1, HbA 1c levels ≤ 7%; group 2, HbA 1c levels > 7%. Venous WBC, neutrophil and lymphocyte counts were determined.Results Of 71 patients included, fasting serum glucose, neutrophil and WBC counts were significantly higher in group 2 compared with group 1. NLR had a positive correlation with HbA 1c .Conclusion There may be a significant relationship between NLR and blood glucose regulation. The authors propose that increased NLR may be associated with elevated HbA 1c in patients with type 2 diabetes mellitus.