Open AccessFaecal calprotectin concentrations in gastrointestinal diseases
Author(s) -
Shaodong Wang,
Zhenkai Wang,
Hui Shi,
Hongyan Lü,
Juan Wei,
Boshi Yuan,
Xiaochen Wu,
Fangyu Wang
Publication year - 2013
Publication title -
journal of international medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 57
eISSN - 1473-2300
pISSN - 0300-0605
DOI - 10.1177/0300060513488499
Subject(s) - medicine , calprotectin , gastroenterology , feces , inflammatory bowel disease , microbiology and biotechnology , disease , biology
Objective To quantify faecal calprotectin concentrations in a variety of gastrointestinal disorders in order to determine its diagnostic value.Methods Patients with gastrointestinal symptoms undergoing upper or lower endoscopy and healthy control subjects provided stool samples. Calprotectin was quantified by enzyme-linked immunosorbent assay.Results The study recruited 210 patients with definitively diagnosed gastrointestinal diseases and 50 control subjects. Calprotectin concentrations were significantly higher in patients with ulcerative colitis or Crohn’s disease compared with controls, or patients with colorectal polyps or irritable bowel syndrome. The faecal calprotectin concentration significantly differentiated between inflammatory bowel diseases (IBD) and non-IBD (area under ROC curve 0.949). Calprotectin concentrations were significantly higher in patients with oesophageal polyps or gastric neoplasms than in those with chronic gastritis, stomach ulcers, duodenal ulcers or acute pancreatitis.Conclusion Calprotectin may be a useful noninvasive marker for the diagnosis of IBD.