Open AccessThe role of insulin-like growth factor 1 and its receptor in the formation and development of colorectal carcinoma
Author(s) -
Rong Zhang,
Guo Liang Xu,
Li Yin,
Liangmei He,
Li Ming Chen,
Guo Bao Wang,
Shi Yong Lin,
Guangyu Luo,
Xu Gao,
Hong Shan
Publication year - 2013
Publication title -
journal of international medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 57
eISSN - 1473-2300
pISSN - 0300-0605
DOI - 10.1177/0300060513487631
Subject(s) - insulin like growth factor 1 receptor , medicine , colorectal cancer , adenomatous polyps , familial adenomatous polyposis , carcinogenesis , insulin like growth factor , carcinoma , growth factor , receptor , cancer , oncology , cancer research , gastroenterology , colonoscopy
Objective To investigate the role of insulin-like growth factor (IGF)-1 and its receptor (IGF1R) in the formation and development of colorectal carcinoma.Methods Colorectal tissue and matching serum samples were collected from patients with adenomatous polyps or carcinoma and healthy control subjects. IGF1R mRNA levels were determined via quantitative real-time reverse transcription–polymerase chain reaction. Serum IGF1 was quantified using enzyme-linked immunosorbent assay.Results Serum IGF1 concentrations and mucosal IGF1R mRNA levels were significantly higher in patients with adenomatous polyps ( n = 24) or carcinoma ( n = 13) compared with healthy control subjects ( n = 13). There was a significant positive correlation between serum IGF1 and mucosal IGF1R mRNA in patients with adenomatous polyps.Conclusions High circulating IGF1 concentrations and mucosal IGF1R expression may play important roles in both the formation and development of colorectal carcinoma. IGF1 and its receptor may be activated before carcinogenesis, and may promote the growth and malignant transformation of adenomatous polyps. IGF1 and IGF1R may be useful biomarkers for evaluating the stage and risk of carcinogenesis.