Open AccessClinical evaluation of serum cystatin C and creatinine in patients with chronic kidney disease: A meta-analysis
Author(s) -
Min Zhang,
Xueying Cao,
Guangyan Cai,
Di Wu,
Ri-bao Wei,
Yuan Xiang,
Xueyuan Bai,
Shuwen Liu,
Xiangmei Chen
Publication year - 2013
Publication title -
journal of international medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 57
eISSN - 1473-2300
pISSN - 0300-0605
DOI - 10.1177/0300060513480922
Subject(s) - medicine , cystatin c , renal function , kidney disease , meta analysis , creatinine , cochrane library , urology , randomized controlled trial , inclusion and exclusion criteria , gastroenterology , pathology , alternative medicine
Objective Glomerular filtration rate (GFR) is an important indicator of renal function. This meta-analysis aimed to evaluate the diagnostic value of serum cystatin C (CysC) and serum creatinine (SCr) for estimating GFR in patients with chronic kidney disease.Methods Google Scholar, PubMed®, Cochrane Library and China National Knowledge Infrastructure databases were searched, to identify randomized controlled trials that determined the diagnostic value of CysC and SCr, for estimating GFR in patients with chronic kidney disease.Results The inclusion criteria were met by 17 studies (total number of patients with chronic kidney disease, 2521). Meta-analysis showed that when the diagnostic cut-off value of GFR was 80–90 ml/min/1.73 m 2 , the heterogeneity was modest for CysC ( I 2 = 48%, summary sensitivity [SEN] = 0.803, summary specificity [SPE] = 0.821), but there was no heterogeneity for SCr ( I 2 = 0.0%, SEN = 0.697, SPE = 0.787). Meta-analysis of the studies demonstrated a significant difference between patients with chronic kidney disease and controls, for CysC and SCr.Conclusions This meta-analysis demonstrated significant correlations between CysC, SCr and GFR. CysC was more sensitive, but less specific, than SCr for the estimation of GFR.