z-logo
open-access-imgOpen Access
Clinical application of olfactory ensheathing cells in the treatment of spinal cord injury
Author(s) -
Yaojian Rao,
Wenxiao Zhu,
Huijuan Liu,
Chunxia Jia,
Qiqi Zhao,
Yongjun Wang
Publication year - 2013
Publication title -
journal of international medical research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.421
H-Index - 57
eISSN - 1473-2300
pISSN - 0300-0605
DOI - 10.1177/0300060513476426
Subject(s) - medicine , olfactory ensheathing glia , spinal cord injury , spinal cord , transplantation , therapeutic effect , surgery , rehabilitation , functional independence measure , central nervous system , physical therapy , olfactory bulb , psychiatry
Objectives To investigate the safety and therapeutic efficacy of autologous olfactory ensheathing cell (OEC) transplantation in cervical spinal cord injury (SCI).Methods Patients with cervical SCI of >6 months’ duration were treated with autologous OECs, injected into the area surrounding the SCI under magnetic resonance imaging guidance, twice a week for 4 weeks. Patients were evaluated before treatment and at 3, 6, 12 and 24 months post-treatment, using the American Spinal Injury Association (ASIA) Impairment Scale, the ASIA sensory and motor score and the Functional Independence Measure (FIM) score.Results Eight patients were recruited to the study. Three months after treatment, ASIA and FIM scores had improved significantly compared with pretreatment, though by 1 year no further significant improvements in the ASIA score were seen. The return of substantial sensation and motor activity in various muscles below the injury level was observed in three patients during follow-up. In addition, bladder function was restored in two patients. There were no serious complications postoperatively or during the follow-up period.Conclusions This study provides preliminary evidence of the safety and possible efficacy of autologous OEC transplantation.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here