Open AccessAn intravascular perspective on hyper-acute neutrophil, T-cell and platelet responses: Similarities between human and experimental stroke
Author(s) -
Guido Stoll,
Michael K. Schuhmann,
Bernhard Nieswandt,
Alexander M. Kollikowski,
Mirko Pham
Publication year - 2022
Publication title -
journal of cerebral blood flow and metabolism
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.167
H-Index - 193
eISSN - 1559-7016
pISSN - 0271-678X
DOI - 10.1177/0271678x221105764
Subject(s) - gpvi , platelet , medicine , stroke (engine) , pathophysiology , inflammation , platelet activation , neutrophil extracellular traps , microglia , immunology , pathology , mechanical engineering , engineering
In stroke patients, local sampling of pial blood within the occluded vasculature before recanalization by mechanical thrombectomy emerged as powerful tool enabling insights into ultra-early stroke pathophysiology. Thereby, a strong intravascular inflammatory response hallmarked by hyper-acute neutrophil recruitment, altered lymphocyte composition and platelet activation could be observed. These human findings mirror experimental stroke. Here, neutrophil and T-cell activation are driven by platelets involving engagement of platelet glycoprotein receptor (GP)Ib, GPVI and CD84 as well as α-granule release orchestrating infarct progression. Thus, targeting of early intravascular inflammation may evolve as a new therapeutic strategy to augment the effects of recanalization.