Wiring and plumbing: Oligodendrocyte precursors and angiogenesis in the oligovascular niche | Zendy

Ken Arai | Zendy; Eng H. Lo | Zendy

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Wiring and plumbing: Oligodendrocyte precursors and angiogenesis in the oligovascular niche

Author(s) -

Ken Arai,

Eng H. Lo

Publication year - 2021

Publication title -

journal of cerebral blood flow and metabolism

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.167

H-Index - 193

eISSN - 1559-7016

pISSN - 0271-678X

DOI - 10.1177/0271678x211014979

Subject(s) - angiogenesis , neurovascular bundle , niche , neuroscience , oligodendrocyte , crosstalk , hypoxia (environmental) , white matter , biology , medicine , anatomy , central nervous system , myelin , cancer research , chemistry , ecology , physics , organic chemistry , radiology , oxygen , magnetic resonance imaging , optics

For efficient stroke recovery, the entire neurovascular unit must be repaired. A recent study underscores this concept by highlighting the importance of cellular crosstalk for white mater remodeling. In developing brains and in brains injured by hypoxia, interactions between oligodendrocyte precursors and endothelium play an essential role for physiological and compensatory angiogenesis. Further studies are warranted to build on these emerging findings in the oligovascular niche in order to identify novel therapeutic targets for stroke and other CNS diseases.

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