Open AccessSodium oxybate for the maintenance of abstinence in alcohol-dependent patients: An international, multicenter, randomized, double-blind, placebo-controlled trial
Author(s) -
Julien Guiraud,
Giovanni Addolorato,
Mariangela Antonelli,
HenriJean Aubin,
Andrea de Bejczy,
Aminé Benyamina,
Roberto Cacciaglia,
Fabio Caputo,
Maurice Demattéis,
Anna Ferrulli,
Anna E. Goudriaan,
Antoni Gual,
Otto-Michael Lesch,
Icro Maremmani,
Antonio Mirijello,
David Nutt,
F. Paille,
Pascal Perney,
Roch Poulnais,
Quentin Raffaillac,
Jürgen Rehm,
Benjamin Rolland,
Claudia Rotondo,
Bruno Scherrer,
Nicolás Simón,
Katrin Skala,
Bo Söderpalm,
Lorenzo Somaini,
Wolfgang H. Sommer,
Rainer Spanagel,
Gabriele Vassallo,
Henriëtte Walter,
Wim van den Brink
Publication year - 2022
Publication title -
journal of psychopharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.333
H-Index - 114
eISSN - 1461-7285
pISSN - 0269-8811
DOI - 10.1177/02698811221104063
Subject(s) - randomized controlled trial , discontinuation , placebo , abstinence , medicine , confidence interval , anesthesia , psychiatry , alternative medicine , pathology
Sodium oxybate (SMO) has been shown to be effective in the maintenance of abstinence (MoA) in alcohol-dependent patients in a series of small randomized controlled trials (RCTs). These results needed to be confirmed by a large trial investigating the treatment effect and its sustainability after medication discontinuation.