Open AccessTransgenerational evidence of increases in dopamine D2 receptor sensitivity in rodents: Impact on sensorimotor gating, the behavioral response to nicotine and BDNF
Author(s) -
W. Drew Gill,
Katherine C. Burgess,
Cynthia Vied,
Russell W. Brown
Publication year - 2021
Publication title -
journal of psychopharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.333
H-Index - 114
eISSN - 1461-7285
pISSN - 0269-8811
DOI - 10.1177/02698811211033927
Subject(s) - quinpirole , nicotine , prepulse inhibition , offspring , endocrinology , nucleus accumbens , medicine , dopamine , brain derived neurotrophic factor , psychology , neurotrophic factors , dopamine receptor , dopamine receptor d2 , receptor , biology , schizophrenia (object oriented programming) , pregnancy , psychiatry , genetics
Neonatal quinpirole (NQ) treatment to rats increases dopamine D 2 (DAD 2 ) receptor sensitivity in adult animals. We investigated if increased DAD 2 sensitivity would be passed to the next (F1) generation, and if these animals demonstrated sensorimotor gating deficits and enhanced behavioral responses to nicotine.