Aerobic exercise improves memory and prevents cognitive deficits of relevance to schizophrenia in an animal model | Zendy

Idil Mitsadali | Zendy; B. Terence Grayson | Zendy; Nagi Idris | Zendy; Linzi Watson | Zendy; Matthew Burgess | Zendy; Joanna C. Neill | Zendy

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Aerobic exercise improves memory and prevents cognitive deficits of relevance to schizophrenia in an animal model

Author(s) -

Idil Mitsadali,

B. Terence Grayson,

Nagi Idris,

Linzi Watson,

Matthew Burgess,

Joanna C. Neill

Publication year - 2020

Publication title -

journal of psychopharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.333

H-Index - 114

eISSN - 1461-7285

pISSN - 0269-8811

DOI - 10.1177/0269881120922963

Subject(s) - schizophrenia (object oriented programming) , medicine , cognition , forgetting , repeated measures design , psychology , phencyclidine , cognitive deficit , analysis of variance , anesthesia , cognitive impairment , psychiatry , nmda receptor , statistics , receptor , mathematics , cognitive psychology

Cognitive impairment associated with schizophrenia (CIAS) greatly reduces patients' functionality, and remains an unmet clinical need. The sub-chronic phencyclidine (scPCP) rat model is commonly employed in studying CIAS. We have previously shown that voluntary exercise reverses impairments in novel object recognition (NOR) induced by scPCP. However, there has not been a longitudinal study investigating the potential protective effects of exercise in a model of CIAS. This study aimed to investigate the pro-cognitive and protective effects of exercise on CIAS using the translational NOR and attentional set-shifting tasks (ASST).

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