Do selective serotonin reuptake inhibitors increase the risk of bleeding or mortality following coronary artery bypass graft surgery? A meta-analysis of observational studies | Zendy

Martyn Eckersley | Zendy; Amir Sepehripour | Zendy; Roberto Casula | Zendy; Prakash P Punjabi | Zendy; Thanos Athanasiou | Zendy

Open Access

Do selective serotonin reuptake inhibitors increase the risk of bleeding or mortality following coronary artery bypass graft surgery? A meta-analysis of observational studies

Author(s) -

Martyn Eckersley,

Amir Sepehripour,

Roberto Casula,

Prakash P Punjabi,

Thanos Athanasiou

Publication year - 2018

Publication title -

perfusion

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.653

H-Index - 45

eISSN - 1477-111X

pISSN - 0267-6591

DOI - 10.1177/0267659118765933

Subject(s) - medicine , odds ratio , platelet , confidence interval , serotonin , coronary artery bypass surgery , anesthesia , artery , depression (economics) , cardiology , receptor , economics , macroeconomics

Depressive illness has a high prevalence in patients undergoing coronary artery bypass graft surgery (CABG). The first line treatment for depression are selective serotonin reuptake inhibitors (SSRIs) which inhibit serotonin reuptake in the presynaptic neuronal membrane and uptake by platelets, inhibiting subsequent serotonin-mediated platelet activation. This presents a theoretically increased risk of bleeding and subsequent postoperative mortality. This review aims to investigate the effects of SSRIs on postoperative bleeding, defined as the need for transfusions and re-operation for bleeding, as well as 30-day mortality in patients undergoing CABG.

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