Open AccessImpact of Obstructive Sleep Apnea Syndrome in P300 Latency
Author(s) -
De Oliveira Barros Thiago,
Mendez Raquel,
Caiaffa Rosana,
Tomita Shiro,
Melo Tavares Lima Marco Antonio
Publication year - 2011
Publication title -
otolaryngology–head and neck surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.232
H-Index - 121
eISSN - 1097-6817
pISSN - 0194-5998
DOI - 10.1177/0194599811415823a453
Subject(s) - polysomnography , epworth sleepiness scale , obstructive sleep apnea , apnea , medicine , anesthesia , body mass index , hypopnea , sleep stages , multiple sleep latency test , excessive daytime sleepiness , cardiology , sleep disorder , insomnia , psychiatry
Objective Evaluate the impact and linear correlation between Obstructive Sleep Apnea Syndrome (OSAS) and P300 latency. It also aimed to identify which variables of polysomnography and scales of excessive daytime sleepiness best correlate with the increase in P300 latency. Method This is a survey study, conducted between March 2010 and January 2011, in which polysomnography, scales of sleepiness and P300 latency from 54 patients were analyzed. These results were evaluated in patients with different stages of OSAS, using as independent variables: sleep stages, arousals, apnea/hyponea index(AHI), oxyhemoglobin desaturation and limb movements (PLM). Results All patients were male, mean age 41.3 ± 2.1 years, body mass index of 29.3 ± 1.2 kg/m 2 and hearing threshold in17.1 ± 1.3 dB. According to the AHI, the patients were divided into normal (n = 15), mild (n = 14), moderate (n = 9), and severely increased (n = 16). It was found the following correlations with P300 latency: Epworth scale (r = 0.33; P =. 2), Karolinska scale (r=‐0.14; P =. 55), Stanford scale (r=0.01; P =. 29), sleep efficiency (r = 0.11; P =. 83), percentage of N3(r = ‐0.48; P =. 24) and REM (r = ‐0.18; P =. 13), arousals index (r=0.74; P <. 05), AHI (r = 0.99; P <. 01), oxyhemoglobin desaturation index (r = 0.99; P <. 01), PLM (r=0.44; P <. 01), mean oxyhemoglobin saturation (r = ‐0.84; P <. 01) and minimum oxyhemoglobin desaturation (r = ‐0.85; P <. 01). Conclusion The apnea/hypopnea index, arousals, oxyhemoglobin desaturation index and periodic limb movements were positively correlated with P300 latency ( P <. 05). The average and minimum oxyhemoglobin saturation exhibited negative correlation with P300 latency ( P <. 01). No statistically significant correlation was seen between P300 latency and sleepiness scales, as well as REM and N3 sleep stage percentage.