Open AccessPhthalate Toxicity in Rats and Its Relation to Testicular Dysgenesis Syndrome in Humans
Author(s) -
Cynthia J. Willson
Publication year - 2021
Publication title -
toxicologic pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.613
H-Index - 108
eISSN - 1533-1601
pISSN - 0192-6233
DOI - 10.1177/01926233211045331
Subject(s) - dysgenesis , phthalate , in utero , toxicity , physiology , gonadal dysgenesis , etiology , endocrinology , medicine , biology , pregnancy , fetus , anatomy , chemistry , genetics , organic chemistry
This work describes the relevance of toxicology studies of environmental chemicals, with a focus on phthalates, for a hypothesis that certain human male reproductive disorders and diseases have a common etiology of disturbance of normal development in utero. The "Testicular Dysgenesis Syndrome" hypothesis in humans has parallels in male reproductive tract abnormalities and microscopic lesions reported for phthalate toxicity in rats. Additionally, this work describes the histological findings of abnormal testicular development (testicular dysgenesis) in rats as compared to those in humans, as well as potential findings in rats at different ages, from the embryo to the adult.