Premium
Can Androgen Therapy Replete Lean Body Mass and Improve Muscle Function in Wasting Associated With Human Immunodeficiency Virus Infection?
Author(s) -
Bhasin Shalender,
Javanbakht Marjan
Publication year - 1999
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/014860719902300605
Subject(s) - wasting , lean body mass , testosterone (patch) , medicine , androgen , enteral administration , androgen deficiency , adverse effect , human immunodeficiency virus (hiv) , endocrinology , immunology , parenteral nutrition , hormone , body weight
A significant number of men who are infected with the human immunodeficiency virus (HIV) have low testosterone levels. Androgen deficiency in HIV‐infected patients is associated with decreased muscle mass and function, and adverse disease outcome. Administration of replacement doses of testosterone to healthy hypogonadal men augments lean body mass, muscle size, and maximal voluntary strength. Recent studies have shown that physiologic testosterone replacement in HIV‐infected men with weight loss who have low testosterone levels can also increase muscle mass and effort‐dependent strength. However, further studies are needed to determine whether androgen therapy can improve physical function and health‐related outcomes in HIV‐infected men. (Journal of Parenteral and Enteral Nutrition23:S195‐S201, 1999)