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Effect of IGF‐1 on Protein Metabolism in Burned Rats
Author(s) -
Tashiro Tsuguhiko,
Sugiura Toshiyuki,
Morishima Yuuichi,
Shimoda Naoshi,
Yamamori Hideo,
Takagi Kazuya,
Nakajima Nobuyuki
Publication year - 1999
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/014860719902300523
Subject(s) - medicine , endocrinology , enteral administration , protein metabolism , parenteral nutrition , albumin , spleen , skeletal muscle , protein catabolism , immune system , metabolism , catabolism , protein biosynthesis , intestinal mucosa , insulin like growth factor , growth factor , serum albumin , biology , small intestine , anabolism , immunology , biochemistry , amino acid , receptor
The effects of insulin‐like growth factor‐1 (IGF‐1) on the catabolic and immune response induced by thermal injury were studied in burned rats fed by TPN. An increase of synthesis greater than the increase of breakdown resulted in improved nitrogen retention in the IGF‐1 group. There was no effect on the mRNA in the structural proteins of the skeletal muscle and liver. However, the gene expression of albumin and the structural proteins of the diaphragm increased significantly in the rats receiving IGF‐1. The proliferation of the gut mucosa and the fractional protein synthesis rate of the small intestine increased, and the endotoxin content of the liver and spleen were smaller in the burned rats that received IGF‐1. Delayed type hypersensitivity increased significantly (p <.01) in the IGF‐1 group. In conclusion, IGF‐1 improved the whole‐body protein metabolism, and albumin and respiratory muscle protein synthesis in the burned rats. It significantly promoted the proliferation of the intestinal mucosa, and reduced the intestinal translocation of endotoxin. Cellular immunity was also enhanced. (Journal of Parenteral and Enteral Nutrition23:S93‐S97, 1999)