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Parenteral Feeding Alters the Fatty Acid Composition of Serum Phospholipids of Rabbits
Author(s) -
Moss R. Lawrence,
Enomoto T. Miko,
Haynes Allan,
Fry Donald E.,
Glew Robert H.
Publication year - 1998
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/014860719802200298
Subject(s) - parenteral nutrition , docosahexaenoic acid , phospholipid , enteral administration , fatty acid , medicine , biology , endocrinology , arachidic acid , biochemistry , composition (language) , polyunsaturated fatty acid , palmitic acid , linguistics , philosophy , membrane
Background: Cholestatic liver disease develops in 30% to 70% of neonates receiving total parenteral nutrition (TPN). We analyzed the fatty acid composition of serum phospholipids from control and TPN‐fed rabbits to determine if TPN altered the fatty acid profile. Methods: Eleven male New Zealand White rabbits aged 9 to 11 weeks received TPN, whereas 11 other rabbits were offered standard laboratory rabbit chow ad libitum. After 14 days on the prescribed diet, serum samples were analyzed for their phospholipid fatty acid content by gas chromatography. Results: The proportions of palmitolenic (16:2n7), α‐linolenic (18:3n3), arachidic (20:0), and eicosaenoic (20:1n9) acids were significantly lower in the serum phospholipids of the TPN‐fed animals compared with the control group. The proportion of docosahexaenoic acid (22:6n3), a fatty acid that is critical to the development of the nervous system, was increased two‐ to threefold. Conclusions: The differences in proportions of fatty acids observed between control and TPN‐fed animals indicate that fatty acid elongation and desaturation pathways are perturbed in rabbits on TPN. ( Journal of Parenteral and Enteral Nutrition 22: 98–101, 1998)