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Triglyceride Hydrolysis of Soy Oil vs Fish Oil Emulsions
Author(s) -
Oliveira Fernanda L.C.,
Rumsey Steven C.,
Schlotzer Ewald,
Hansen Inge,
Carpentier Yvon A.,
Deckelbaum Richard J.
Publication year - 1997
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607197021004224
Subject(s) - fish oil , emulsion , eicosapentaenoic acid , hydrolysis , triglyceride , glyceride , chemistry , omega 3 fatty acid , docosahexaenoic acid , fatty acid , lipoprotein lipase , corn oil , lipase , food science , chromatography , biochemistry , polyunsaturated fatty acid , cholesterol , fish <actinopterygii> , biology , enzyme , fishery
Background: Fish oil triglycerides (TG) are being considered for use in IV lipid emulsions, but the characteristics of their lipase‐mediated clearance from plasma are largely unknown. Methods: We compared the in vitro hydrolysis of soy oil long‐chain triglyceride emulsions (LCT) and fish oil emulsions (ω‐3) using lipoprotein (LPL) and hepatic (HL) lipases. ω‐3 emulsions contained 18% and 28% of total TG fatty acid as eicosapentaenoic acid (EPA) and docosahexanoic acid (DHA), respectively. Results: Under conditions of maximal hydrolysis, total free fatty acid (FFA) release was two‐ to threefold greater with LCT compared with ω‐3 emulsions. Also, EPA and DHA together contributed proportionally much less than other fatty acids (<20%) to FFA released from ω‐3 emulsions. In mixtures of LCT emulsion with ω‐3 emulsions, the presence of >20% of w‐3 particles substantially inhibited LCT emulsion hydrolysis (by up to 50%). Conclusions: Our results suggest that, during infusion of ω‐3 emulsions, EPA and DHA may enter cells as TG or partial glycerides within emulsion particles and not as FFA and that coinfusion of ω‐3 emulsion with LCT emulsion at low w‐3:LCT emulsion ratios (up to 20% of total triglyceride as w‐3) will not substantially inhibit LCT hydrolysis. (Journal of Parenteral and Enteral Nutrition 21:224–229, 1997)