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Effect of Medium‐Chain Triglyceride Emulsion in Total Parenteral Nutrition on Experimental Hepatic Metastasis in the Rat
Author(s) -
Ohkawa Akira,
Sato Nobuaki,
Hatakeyama Katsuyoshi
Publication year - 1997
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607197021004220
Subject(s) - parenteral nutrition , emulsion , triglyceride , metastasis , medicine , calorie , fat emulsion , lipid emulsion , gastroenterology , medium chain triglyceride , cancer , chemistry , cholesterol , biochemistry
Background: This study evaluated the effect of total parenteral nutrition (TPN) regimens containing a medium‐chain triglyceride (MCT) emulsion on tumor metastasis. Methods: Tumor metastasis development was assessed by the number of metastatic foci on the liver surface in rats inoculated with ACL‐15 tumor cells via the portal vein. Rats received one of the following TPN regimens: TPN containing an MCT emulsion (group M), in which tricaprylin emulsion served as the MCT and comprised 50% of nonprotein calories (NPC); TPN containing a long‐chain triglyceride (LCT) emulsion (group L), in which soybean oil served as the LCT and comprised 50% of NPC; and TPN without lipid emulsion (group G), in which dextrose comprised 100% of NPC. Results: The number of metastatic foci was greatest in rats receiving TPN containing the MCT emulsion on day 11 after tumor cell inoculation and either 11 days of TPN or 2 days of TPN followed by 9 days standard rat chow. Conclusions: TPN containing MCT emulsion increases liver metastasis early in its administration. (Journal of Parenteral and Enteral Nutrition 21:220–223, 1997)