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The Accumulation and Energy Load of Exogenous Lipids in Cirrhotic Rat Liver After Partial Hepatectomy
Author(s) -
Matsui Yoichi,
Nakagawa Akihiko,
Kasamatsu Satoshi,
Nakagawa Manabu,
Hiramatsu Yoshifumi,
Kamiyama Yasuo
Publication year - 1995
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607195019004313
Subject(s) - energy charge , hepatectomy , medicine , glycogen , endocrinology , chemistry , cirrhosis , thioacetamide , calorie , hepatocyte , biochemistry , adenylate kinase , surgery , receptor , resection , in vitro
Background: The suitability of three energy substrates, glucose, medium‐chain triglycerides (MCT) and long‐chain triglycerides (LCT), was studied in cirrhotic rats after a partial hepatectomy. Methods: Rats with thioacetamide‐induced cirrhosis underwent a 70% hepatectomy, and were divided into three groups. Each group was then injected with 14 C‐labeled glucose, 14 C‐labeled MCT or 14 C‐labeled LCT, respectively. The subsequent tissue distribution of 14 C and the cumulative amount of expired 14 CO 2 were determined. In a second experiment, the 70%‐hepatectomized cirrhotic rats received total parenteral nutrition (TPN). The source of the nonprotein calories was 100% glucose (glucose group), 60% MCT + 40% glucose (MCT group), and 60% LCT + 40% glucose (LCT group). The adenylate energy charge and the glycogen content in the liver remnant were determined. Results: The tissue distribution of 14 C revealed that the fat emulsions accumulated preferentially in the liver. One hour after the partial hepatectomy, the concentration of 14 C‐labeled MCT in the liver remnants was threefold higher than in sham‐operated controls. Similarly, the concentration of 14 C‐labeled LCT was twofold higher. The adenylate energy charge in the glucose group with TPN recovered to preoperative levels within 1‐hour after the partial hepatectomy, whereas the LCT group with TPN showed a 24‐hour delay in their recovery. The MCT group with TPN exhibited an intermediate time course. Conclusions: It is suggested that the specific accumulation of MCT and especially LCT emulsions in the cirrhotic liver remnant acts as an energy load rather than an energy substrate. Uournal of Parenteral and Enteral Nutrition 19: 313–318, 1995)