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Review: Nitric Oxide, Sepsis, and Arginine Metabolism
Author(s) -
Kelly Edward,
Morris Sidney M.,
Billiar Timothy R.
Publication year - 1995
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607195019003234
Subject(s) - nitric oxide , arginine , sepsis , nitric oxide synthase , chemistry , metabolism , medicine , pharmacology , biochemistry , immunology , amino acid
Nitric oxide is one of the most versatile molecules produced by mammalian cells. Its role in sepsis and inflammation has been the subject of intense investigation since its discovery as a cell product in 1987. The role of arginine in sepsis and trauma has also received considerable attention, but most of the earlier studies on arginine preceded the studies on nitric oxide and the discovery that arginine serves as the nitrogen donor for nitric oxide synthesis. This review will explore the role that nitric oxide plays in sepsis and the effects of arginine metabolism on nitric oxide synthesis. ( Journal of Parenteral and Enteral Nutrition 19:234–238, 1995)