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Amino Acid Loss and Plasma Concentration During Continuous Hemodiafiltration
Author(s) -
Frankenfield David C.,
Badellino Michael M.,
Reynolds H. Neal,
Wiles Charles E.,
Siegel John H.,
Goodarzi Shirin
Publication year - 1993
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607193017006551
Subject(s) - amino acid , calorie , nitrogen balance , urea , chemistry , parenteral nutrition , medicine , renal function , endocrinology , nitrogen , biochemistry , organic chemistry
Amino acid loss, plasma concentration, and the relationship between amino acid intake and balance during continuous hemodiafiltration (CHD) were investigated in a prospective, nonrandomized study of trauma patients exhibiting the systemic inflammatory response with acute renal failure. Data were compared with those from a group of similar patients who had maintained renal function (control). Both groups received similar amounts of nonprotein calories (3015 ± 753 nonprotein calories per day in the control group vs 3077 ± 1018 nonprotein calories per day in the CHD group) and amino acids (2.24 ± 0.36 g/kg per day in the control group vs 2.19 ± 0.48 g/kg per day in the CHD group) via the parenteral route. Amino acid solutions were either 19% or 45% branched‐chain amino acid enriched. Studies were performed every 12 hours for a maximum of 6 days. Amino acid loss was 2.5 ± 2.3 g/12 h in the control group vs 6.6 ± 2.4 g/12 h in the CHD group ( p <.0001). Increasing the dialysate rate from 15 to 30 mL/min increased amino acid loss from 5.7 ± 1.7 to 7.9 ± 2.6 g/12 h ( p <.0001). Amino acid loss was unrelated to amino acid intake but was directly related to plasma amino acid concentration, CHD effluent volume, and the efficiency of filtration as measured by the ratio of filtered urea nitrogen to blood urea nitrogen ( R 2 =.69). A linear relationship was found between amino acid intake and balance ( R 2 =.991). The patterns of plasma amino acid concentrations were consistent with metabolic changes wrought by a combination of sepsis and multiple organ dysfunction and type of amino acid intake but seemed unaffected by increased amino acid loss in CHD effluent. Amino acid losses were 2 to 3 times greater from CHD than from normal kidney. However, CHD amino acid losses may not be clinically significant unless amino acid intake is restricted to levels used typically in traditional hemodialysis. ( Journal of Parenteral and Enteral Nutrition 17 :551–561, 1993)