Premium
Serum Vitamin K Concentration in Pediatric Patients Receiving Total Parenteral Nutrition
Author(s) -
Pettei Michael J.,
Israel David,
Levine Jeremiah
Publication year - 1993
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607193017005465
Subject(s) - parenteral nutrition , medicine , multivitamin , vitamin , dietary reference intake , reference daily intake , pediatrics , gastroenterology , nutrient , chemistry , environmental health , organic chemistry
The only multivitamin preparation for total parenteral nutrition currently available in the United States that contains vitamin K is the pediatric formulation MVI‐Pediatric. The recommended dose provides 200 μg of vitamin K 1 per day to term infants and children up to 11 years old. This dose is well above the recommended dietary allowance of approximately 1 μg/kg per day, but the losses of vitamin K during administration are unknown. We evaluated the stability of vitamin K 1 in a standard total parenteral nutrition infusion and found that on average 72.7 ± 4.9% of the original vitamin K 1 was present after 24 hours. By using high‐performance liquid chromatography with electrochemical reduction and fluorescence detection, we obtained the serum vitamin K 1 concentrations in 11 pediatric patients receiving total parenteral nutrition with MVI‐Pediatric (Rorer Pharmaceuticals, Fort Washington, PA) supplementation and in control children. The serum vitamin K 1 concentration (19.3 ± 12.2 ng/mL) in patients receiving MVI‐Pediatric is significantly higher than that in control children 1.9 ± 1.5 ng/mL (p <.001). Current practice results in excessive levels of vitamin K in pediatric patients. ( Journal of Parenteral and Enteral Nutrition 17: 465–467, 1993)