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Resting Energy Expenditure, Caloric Intake, and Short‐Term Change in HIV Infection and AIDS C. GRUNFELD, M. PANGE, L. SHIMIZU, ET AL American Journal of Clinical Nutrition 55:455–460, 1992
Author(s) -
Bell Stacey J.,
Chavali Sambasiva,
Baumer Julie,
Forse R. Armour
Publication year - 1993
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607193017004392
Subject(s) - medicine , weight loss , calorie , resting energy expenditure , caloric intake , caloric theory , weight change , human immunodeficiency virus (hiv) , etiology , body weight , physiology , pediatrics , immunology , obesity
Patients with AIDS often develop malignancies and secondary infections that cause weight loss. To examine the etiology of this weight loss, the investigators examined patients with HIV, AIDS, and AIDS plus secondary infection (AIDS‐SI) for resting energy expenditure (REE), caloric intake, and short‐term weight change over a 28‐day period. Although caloric intake during that period for HIV positive and AIDS patients was similar to that of control subjects, it was 36% lower for AIDS‐SI patients. The HIV positive and AIDS subjects showed no short‐term change in weight, whereas the AIDS‐SI subjects demonstrated a 5% weight loss. The HIV positive, AIDS, and AIDS‐SI groups exhibited an increase over controls in REE of 11%, 25%, and 29%, respectively. Thus, the AIDS‐SI patients consumed 17% fewer calories than would be needed to support the elevated REE, which accounted for the weight loss over the 28 days. Consequently, a hypermetabolic effect caused by the existence of a secondary infection coupled with the HIV infection results in an increase of REE that is not counterbalanced with daily dietary intake. This causes significant weight loss over a short period of time.