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Intravenous Glutamine Fails To Improve Gut Morphology After Radiation Injury
Author(s) -
Scott Thomas Edward,
Ross Moellman Jeffrey
Publication year - 1992
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607192016005440
Subject(s) - glutamine , parenteral nutrition , medicine , small intestine , abdomen , surgery , gastroenterology , biochemistry , biology , amino acid
Male Sprague‐Dawley rats housed in individual metabolic cages received total parenteral nutrients via chronic indwelling internal jugular catheters to determine whether supplementing parenteral nutrition with glutamine would accelerate recovery of small‐bowel morphology after abdominal radiation. After recovering from catheter insertion for 3 days they received either 1000 cGy gamma radiation to the abdomen only or no radiation and immediately thereafter received iso‐nitrogenous and isocaloric intravenous solutions containing either 0% or 2% glutamine at 1.58 mL/h for the next 5 days. Intestinal segments were then assayed for whole‐bowel deoxyribose nucleic acid content and villus height. Irradiation caused a 40% decrement in these parameters, which were not restored by glutamine supplementation. Therefore, intravenous glutamine supplementation failed to accelerate recovery of small‐bowel morphology in this model of combined surgical and radiation injury. ( Journal of Parenteral and Enteral Nutrition 16: 440–444, 1992)