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Effects of Pectin and Cellulose on Fat Absorption After Massive Small‐Bowel Resection in Weanling Rats
Author(s) -
Toki Akira,
Todani Takuji,
Watanabe Yasuhiro,
Uemura Sadashige,
Sato Yasuhisa,
Morotomi Yoshiki
Publication year - 1992
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607192016003255
Subject(s) - weanling , pectin , absorption (acoustics) , chemistry , cellulose , enteral administration , jejunum , short bowel syndrome , absorption rate , resection , medicine , biochemistry , parenteral nutrition , surgery , chromatography , physics , acoustics
The effects of pectin and cellulose on fat absorption after massive small‐bowel resection were studied in rats. Weanling Wistar rats underwent 80% resection of the small intestine with gastrostomy, and fat emulsion labeled with 14 C‐linoleate was given via a gastrostomy tube for the fat absorption test on the 10th postoperative day. They were classified into three groups by diet as follows: E group, a fiber‐free, chemically defined diet (CDD); EP group, CDD with 2% pectin; and EC group, CDD with 2% cellulose. The cumulative and hourly output of 14 C in the expired air, the absorption rate of 14 C in the intestine, and the metabolic utilization rate of 14 C were calculated. The cumulative 14 CO 2 output was significantly lower in the EC group than in the E and EP groups. However, there was no significant difference in the 14 CO 2 output between the E and EP groups. The highest hourly 14 CO 2 output in the E and EP groups was observed during the first 2 hours. However, in the EC group, this fluctuated at low levels. No significant difference in the 1‐ 14 C‐linoleate absorption rate was observed between the E and EP groups, whereas it was significantly lower in the EC group than in the E and EP groups. The metabolic utilization rate of 1‐ 14 C‐linoleate showed no significant difference among the three groups. These data suggest that an addition of pectin to CDD does not impair small intestinal absorption of 1‐ 14 C‐linoleate after massive small‐bowel resection, and an addition of cellulose decreases absorption of 1‐ 14 C‐linoleate. (Journal of Parenteral and Enteral Nutrition 16: 255–258, 1992)