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Vitamin E Status of Patients Receiving Long‐Term Parenteral Nutrition: Is Vitamin E Supplementation Adequate?
Author(s) -
Steephen Anita C.,
Traber Maret G.,
Ito Yasushi,
Hornsby Lewis Lynn,
Kayden Herbert J.,
Shike Moshe
Publication year - 1991
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607191015006647
Subject(s) - parenteral nutrition , vitamin e , medicine , adipose tissue , endocrinology , tocopherol , alpha tocopherol , vitamin , cholesterol , chemistry , antioxidant , biochemistry
Vitamin E status of eight patients receiving total parenteral nutrition (TPN), including 10 IU of all‐racemic α‐tocopheryl acetate daily and Intralipid 20% (500 mL; 12 mg of RRR‐α‐ and 92 mg of RRR‐γ‐tocopherols) two to three times per week for 69 ± 45 (mean ± SD) months was assessed by measuring plasma and adipose tissue tocopherol concentrations. Plasma α‐tocopherols of TPN patients were similar to controls (17.5 ± 6.6 μmol/L vs 22.4 ± 5.1), whereas γ‐tocopherols were significantly reduced (6.0 ± 3.1 vs 11.2 ± 3.6, p < 0.03). The adipose tissue α‐ and γ‐tocopherol/triglycerides (TG) were similar (369 ± 215 nmol/mmol vs 452 ± 228, and 125 ± 102 vs 140 ± 130, respectively), but cholesterol/TG were increased in the TPN patients (7.8 ± 2.5 μmol/mmol vs 5.1 ± 3.5, p < 0.05), suggesting that adipose tissue was relatively TGdepleted and tocopherol/cholesterol measurements better reflect vitamin E status. The mean α‐tocopherol/cholesterol ratios were significantly lower in the TPN patients than the controls (55 ± 36 vs 106 ± 63, p < 0.04). Thus, current vitamin E supplementation of TPN patients seems insufficient for maintenance of adequate tissue stores. ( Journal of Parenteral and Enteral Nutrition 15:647–652, 1991)