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Increased Lipoprotein X Causes Hyperlipidemia During Intravenous Administration of 10% Fat Emulsion in Man
Author(s) -
Tashiro Tsuguhiko,
Mashima Yoshiya,
Yamamori Hideo,
Horibe Kazuo,
Nishizawa Masahiko,
Sanada Masao,
Okui Katsuji
Publication year - 1991
Publication title -
journal of parenteral and enteral nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.935
H-Index - 98
eISSN - 1941-2444
pISSN - 0148-6071
DOI - 10.1177/0148607191015005546
Subject(s) - fat emulsion , hyperlipidemia , medicine , emulsion , administration (probate law) , lipid emulsion , parenteral nutrition , endocrinology , chemistry , biochemistry , diabetes mellitus , political science , law
To clarify the mechanisms of hyperlipidemia during intravenous Intralipid 10%, lipoprotein profiles including lipoprotein X were studied in 13 patients receiving 2.0 g of fat per kilogram per day by Intralipid 10% over a period of 8 weeks. All patients were fed exclusively by total parenteral nutrition providing 1.1 g of amino acid and 30 kcal/kg per day. Intravenous administration of Intralipid 10% caused a marked increase of low‐density lipoprotein (LDL), phospholipid, and cholesterol, especially free cholesterol, whereas triglyceride, very‐low‐density lipoprotein, and high‐density lipoprotein remained within the normal range. Lipid composition of LDL approximated that of lipoprotein X progressively with the intravenous Intralipid 10%. Quantification of lipoprotein X revealed that its increase was proportionate with that of LDL and total lipid. From these findings, hyperlipidemia during intravenous Intralipid 10% is induced almost exclusively by the increased lipoprotein X. ( Journal of Parenteral and Enteral Nutrition 15: 546–550, 1991)